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副教授
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张静柏
发布时间:2017-02-22

                             

基本信息


姓名: 张静柏 出生年月: 1979.9

性别: 硕/博导:

民族: 开设课程: 植物病害流行学、园艺植物病理学

职称: 副教授 研究方向: 分子植物病理学

学位: 农学博士


联系方式
电子邮件:jingbozhang@mail.hzau.edu.cn


个人简介
张静柏,女,1979年生,博士,365bet体育教师。1998-2002年就读于于河北农业大学植物保护专业,2002-2008年就读于bet体育在线官网攻读植物病理学专业博士学位,2008年1月获农学博士学位,毕业留校任教,承担《农业植物病理学实验》、《植物病害流行学》、《园艺植物病理学》、《园林植物病理学》等课程教学。2017年6月-2018年6月在美国麻省大学阿默斯特分校进行访学研究。从事镰刀菌分子生物学、镰刀菌及其毒素特异抗体分离与毒素分析检测、镰刀菌与植物互作分子生物学、植物抗病及病菌致病相关基因克隆鉴定等方面研究,主持相关国家自然基金青年科学基金、教育部高等学校博士学科点专项新教师基金、武汉市科技攻关计划项目各1项,曾作为主要参与者完成国家“973”、“中德国际合作重点项目”多个国家课题,现作为骨干力量加入国家重大科技专项-转基因新品种培育1项、国家重点研发计划项目1项,共计发表研究论文40余篇(SCI论文30余篇),授权或申请专利15项,其中国际专利1项。


承担的科研项目

1. 横向项目:湖北省小麦赤霉病菌毒素检测及新型抗病资源的开发,2018-2020,主持

2. 国家重点研发计划:湖北麦区小麦化肥农药增效减施技术集成研究与示范,2018-2020,加入

3. 国家重大科技专项:抗赤霉病转基因小麦新品系培育,2016-2020,加入

4. 国家科技重大专项转基因生物新品种培育项目:高抗赤霉病和毒素转基因小麦新品种培育,2014-2016,加入

5. 国家自然科学基金青年科学基金项目:赤霉菌致病相关基因CR1 的鉴定和功能分析,2013-2015,主持

6. 武汉市科技计划项目:抗伏马菌素特异重组抗体的分离及应用,2013-2014,主持

7. 国家自然科学基金面上项目:抗病抗体识别的赤霉病菌表面抗原基因克隆与功能鉴定,2013-2016,加入

8. 农业部重大专项:抗赤霉病转基因小麦新品系和新种质创制,2011-2015,加入

9. 教育部新教师基金:我国长江中下游小麦、玉米赤霉菌系统群及产毒性比较研究,2009-2012,主持


发明专利及获奖情况

部分授权专利

1) 廖玉才,李和平,张静柏,杨鹏. 一种禾谷镰刀菌葡聚糖合成酶基因GLS及应用. 授权日:2019.12.13

2) 廖玉才;宫安东;李和平;张静柏. 防治作物储藏期黄曲霉菌及毒素的海藻希瓦氏菌及其应用. 授权日:2018.04.10

3) 廖玉才,宫安东,李和平,张静柏. 一株防治小麦赤霉病的解淀粉芽孢杆菌及其应用. 授权日:2017.08.15

4) 廖玉才,李和平,胡祖权,张静柏. 抗伏马菌素B1的单克隆重组抗体H2.  授权日:2015.01.28

5) 廖玉才,李和平,胡祖权,张静柏. 抗伏马菌素B1的单克隆重组抗体H7. 授权日:2015.01.28

6) 廖玉才,胡祖权,李和平,张静柏. 镰刀菌特异单链抗体及制备方法和应用.授权日:2014.09.10

7) 廖玉才,王建华,李和平,张静柏,黄涛. 一种镰刀菌单端孢霉烯族A类毒素的分子鉴定方法. 授权日:2014.06.18

8) 廖玉才,王建华,李和平,张静柏,黄涛,瞿波. 玉米赤霉烯酮毒素的分子检测方法及应用. 授权日:2014.04.02


获奖情况

2014年获得bet体育在线官网教学质量三等



发表的论文及著作


第一作者或通讯作者文章

1. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Zhao, Y., Wu, A.-B., Dong, W.-B., Li, H.-P., Zhang, J.-B*. Liao, Y.-C*. A quinone-dependent dehydrogenase and two NADPH-dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain. Food Chemistry, 2020, 321: 126703. https://doi.org/10.1016/j.foodchem.2020.126703(共同通讯作者)

2. Gong, A.-D., Sun, G.-J., Zhao, Z.-Y., Liao, Y.-C., Zhang, J.-B*. Staphylococcus saprophyticus L-38 produces volatile, 3-dimethyl-1,2-epoxybutane with strong inhibitory activity against Aspergillus flavus germination and aflatoxin production. World Mycotoxin Journal, 2020: 13 (2): 247-258

3. Hu, Z.-Q., Li, H.-P., Liu, J.-L., Xue, S., Gong, A.-D., Zhang, J.-B*., Liao, Y.-C. Production of a phage-displayed mouse scFv antibody against Fumonisin B1 and molecular docking analysis of their interactions. Biotechnology and Bioprocess Engineering, 2016, 21: 134-143.

4. Wang, J.-H., Zhang, J.-B.#, Li, H.-P., Gong, A.-D., Liao, Y.-C. Molecular identification, mycotoxin production and comparative pathogenicity of Fusarium temperatum isolated from maize in China . Journal of Phytopathology, 2014, 162: 147-157.(共同第一作者)

5. Zhang, J.-B., Wang, J.-H., Gong, A.-D., Chen, F.-F., Song, B., Li, H.-P., Li, X., Peng, C.-H., Liao Y.-C*. Natural occurrence of Fusarium head blight, mycotoxins, and mycotoxin-producing strains of Fusarium in commercial fields of wheat in Hubei. Plant Pathology, 2013, 62: 92-102.

6. Li, X., Zhang, J.-B.#, Song, B., Li, H.-P., Xu, H. Q., Qu, B., Dang, F.-J., Liao, Y.-C*. Resistance to Fusarium head blight and seedling blight in wheat is associated with activation of a cytochrome P450 gene. Phytopathology, 2010, 100:183-191. (共同第一作者)

7. Li, H.-P., Zhang, J.-B.#, Shi, R.-P., Huang, T., Fischer, R., Liao, Y.-C. Engineering Fusarium head blight resistance in wheat by expression of a fusion protein containing a Fusarium-specific antibody and an antifungal peptide. Molecular Plant-Microbe Interaction, 2008, 21:1242-1248. (共同第一作者)

8. Zhang, J.-B., Li, H.-P., Dang, F.-J., Qu, B., Xu, Y.-B., Zhao, C.-S., Liao, Y.-C. Determination of the trichothecene mycotoxin chemotypes and associated geographical distribution and phylogenetic species of the Fusarium graminearum clade from China. Mycological Research, 2007, 111:967-975.

9. 胡祖权,李和平,刘锦龙,吴平,廖玉才,张静柏*. 抗伏马菌素B1单克隆重组抗体的筛选. 基因组学与应用生物学,201534(9)1912-1916

10. 胡祖权,李和平,吴平,廖玉才,张静柏*. 抗镰刀菌单链抗体在大肠杆菌中可溶性表达条件的研究. 生物技术通报,201531(9)238-243


其他作者英文文章

1. Guo, M.-W., Yang, P., Zhang, J.-B., Liu, G., Yuan, Q.-S, He, W.-J., Nian, J.-N., Yi, S.-Y, Huang, T., Liao, Y.-C. Expression of microRNA-like RNA-2 (Fgmil-2) and bioH1 from a single transcript in Fusarium graminearum are inversely correlated to regulate biotin synthesis during vegetative growth and host infection, Molecular plant pathology, 2019, 20(11): 1574-1581.

2. Song, X.-S., Xing, S., Li, H.-P., Zhang, J.-B., Qu, B., Jiang, J.-H., Fan, C., Yang, P., Liu, J.-L., Hu, Z.-Q., Xue, S., Liao, Y.-C*. An antibody that confers plant disease resistance targets a membrane-bound glyoxal oxidase in Fusarium. New Phytologist, 2016, 210(3): 997-1010.

3. He, W.-J., Yuan, Q.-S, Zhang, Y.-B., Guo, M.-W., Gong, A,-D., Zhang, J.-B., Wu, A.-B., Huang, T., Qu, B., Li, H.-P., Liao, Y.-C. Aerobic de-Epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment. Toxins, 2016, 8, 277. doi:10.3390/toxins8100277

4. Cheng, W., Song, X.-S., Li, H.-P., Cao, L.-H., Sun, K., Qiu, X.-L., Xu, Y.-B., Yang, P., Huang, T., Zhang, J.-B., Qu, B., Liao, Y.-C. Host-induced gene silencing of an essential chitin synthase gene confers durable resistance to Fusarium head blight and seedling blight in wheat. Plant Biotechnology Journal, 2015, 13, 1335-1345.

5. Cheng, W., Li, H.-P., Zhang, J.-B., Du, H.-J., Wei, Q.-Y., Huang, T., Yang, P., Kong, X.-W., Liao, Y.-C. Tissue-specific and pathogen-inducible expression of a fusion protein containing a Fusarium-specific antibody and a fungal chitinase protects wheat against Fusarium pathogens and mycotoxins. Plant Biotechnology Journal, 2015, 13: 664-674.

6. Gong, A,-D., Li, H.-P., Shen, L., Zhang, J.-B., Wu, A.-B., He, W.-J., Yuan, Q.-S., He, J.-D., Liao, Y.-C. The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins. Frontiers in Microbiology, 2015, Oct 6. doi: 10.3389/fmicb.2015.01091.

7. Hu, Z.-Q., Li, H.-P., Wu, P., Li, Y.-B., Zhou, Z.-Q., Zhang, J.-B., Liu, J.-L., Liao, Y.-C*. An affinity improved single-chain antibody from phage display of a library derived from monoclonal antibodies detects fumonisins by immunoassay. Analytica Chimica Acta, 2015, 867: 74-82.

8. Gong, A.-D., Li, H.-P., Yuan, Q.-S., Song, X.-S., Yao, W., He, W.-J., Zhang, J.-B., Liao, Y.-C. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS ONE, 2015 Feb 17;10(2):e0116871. doi: 10.1371/journal.pone.0116871.

9. Song, X.-S., Li, H.-P., Zhang, J.-B., Song, B., Huang, T., Du, X.-M., Gong, A.-D., Liu, Y.-K., Feng, Y.-N. Agboola, R.S., Liao, Y.-C. Trehalose 6-phosphate phosphatase is required for development, virulence and mycotoxin biosynthesis apart from trehalose biosynthesis in Fusarium graminearum. Fungal Genetics and Biology, 2014, 63: 24-41.

10. Wang, J.-H., Li, H.-P., Zhang, J.-B., Wang, B.-T., Liao, Y.-C. First report of Fusarium maize ear rot caused by Fusarium kyushuense in China . Plant Disease, 2014, 98: 279-280. DOI: 10.1094/PDIS-05-13-0558-PDN.

11. Xue, S., Li, H.-P., Zhang, J.-B., Liu, J.-L., Hu, Z.-Q., Gong, A.-D., Huang, T., Liao, Y.-C. Chicken single-chain antibody fused to alkaline phosphatase detects Aspergillus pathogens and their presence in natural samples by direct sandwich enzyme-linked immunosorbent assay. Analytical Chemistry, 2013, 85, 10992–10999.

12. Song, B., Li, H.-P., Zhang, J.-B., Wang, J.-H., Gong, A.-D., Song, X.-S., Chen T., Liao, Y.-C. Type II myosin gene in Fusarium graminearum is required for septation, development, mycotoxin biosynthesis and pathogenicity. Fungal Genetics and Biology, 2013, 54: 60-70.

13. Hu, Z.-Q., Li, H.-P., Zhang, J.-B., Huang, T., Liu, J.-L., Xue, S., Wu, A.-B., Liao, Y.-C. A phage-displayed chicken single-chain antibody fused to alkaline phosphatase detects Fusarium pathogens and their presence in cereal grains. Analytica Chimica Acta, 2013, 764: 84-92.

14. Gao, C.-S., Kou, X.-J., Li, H.-P., Zhang, J.-B., Saad, A. Sefyan I., Liao, Y.-C. Inverse effects of Arabidopsis NPR1 gene on fusarium seedling blight and fusarium head blight in transgenic wheat. Plant Pathology, 2013, 62: 383-392.

15. Liu, Z.-W., Li, H.-P., Cheng, W., Yang, P., Zhang, J.-B., Gong, A.-D., Feng, Y.-N., Fernando, W. G. D., Liao, Y.-C. Enhanced overall resistance to Fusarium seedling blight and Fusarium head blight in transgenic wheat by co-expression of anti-fungal peptides. European Journal of Plant Pathology, 2012, 134: 721-732.

16. Hu, Z.-Q., Liu, J. L., Li, H.-P., Xing, S., Xue, S., Zhang, J.-B., Wang, J.-H., Nölke, G., Liao, Y.-C. Generation of a highly reactive chicken-derived single-chain variable fragment against Fusarium verticillioides by phage display. International Journal of Molecular Sciences, 2012, 13, 7038-7056.

17. Ndoye, M., Zhang, J-B., Wang, J.-H., Gong, A.-D, Qu, B., Li, H.-P., Li, S.-J, Liao, Y.-C. Nivalenol and 15-acetyldeoxynivalenol chemotypes of Fusarium graminearum clade species are prevalent on maize throughout China . Journal of Phytopathology, 2012, 160: 519-524.

18. Wang, J.-H., Zhang, J-B., Chen, F.- F., Li, H.-P., Ndoye M., Liao, Y.-C. A multiplex PCR assay for genetic chemotyping of toxigenic Fusarium graminearum and wheat grains for 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol and nivalenol mycotoxins. Journal of Food, Agriculture and Environment. 2012, 10: 505-511.

19. Liu, J.-L., Hu, Z.-Q., Xing, S., Xue, S., Li, H.-P., Zhang, J.-B., Liao, Y.-C. Attainment of 15-fold higher affinity of a Fusarium-specific single-chain antibody by directed molecular evolution coupled to phage display. Molecular Biotechnology, 2012, 52: 111-122.

20. Liu, G., Han, Z., Nie, D., Yang, J., Zhao, Z. H., Zhang, J. B., Li, H.P., Liao, Y. C., Song, S., Saeger, S. D., Wu, A. B. Rapid and sensitive quantitation of zearalenone in food and feed by lateral flow immunoassay. Food Control, 2012, 27: 200-205.

21. Han, Z., Zhao, Z.-Y., Song, S.-Q., Liu, G., Shi, J.-X., Zhang, J.-B., Liao, Y.-C., Zhang, D.-B., Saeger, S. D., Wu, A.-B. Establishment of a model isotope dilution LC-MS/MS method revealing kinetics and distribution of co-occurring mycotoxins in rat. Analytical Methods, 2012, 4, 3708–3717.

22. Wang, J.-H., Ndoye, M., Zhang, J.-B., Li, H.-P., Liao, Y.-C. Population structure and genetic diversity of the Fusarium graminearum species complex. Toxins, 2011, 3, 1020-1037.

23. Xu, Y.-B., Li, H.-P., Zhang, J.-B., Song, B., Chen, F.-F., Duan, X.-J., Xu, H.-Q., Liao, Y.-C. Disruption of the chitin synthase gene Chs1 from Fusarium asiaticum results in an altered structure of cell walls and reduced virulence. Fungal Genetics and Biology, 2010, 47: 205-215.

24. Wang, J.-H., Li, H.-P., Qu, B., Zhang, J.-B., Huang, T., Chen, F.-F., Liao, Y.-C. Development of a generic PCR detection of 3-acetyldeoxynivalenol-, 15-acetyldeoxynivalenol- and nivalenol-chemotypes of Fusarium graminearum clade. International Journal of Molecular Sciences, 2008, 9:2495-2504.

25. Hu, Z.-Q., Li, H.-P., Zhang, J.-B., Glinka, E., Liao, Y.-C. Antibody-mediated prevention of Fusarium mycotoxins in the field. International Journal of Molecular Sciences, 2008, 9: 1915-1926.

26. Qu, B., Li, H.-P., Zhang, J.-B., Xu, Y.-B., Huang, T., Wu, A.B., Zhao, C.-S., Carter, J., Nicholson, P., Liao, Y.-C. Geographical distribution and genetic diversity of the Fusarium graminearum and F. asiaticum on wheat spikes throughout China . Plant Pathology, 2008, 57: 15-24.

27. Qu, B., Li, H.-P., Zhang, J.-B., Huang, T., Carter, J., Liao, Y.-C., P. Nicholson. Comparison of genetic diversity and pathogenicity of Fusarium head blight pathogens from China and Europe revealed by SSCP and seedling assays on wheat. Plant Pathology, 2008, 57:642-651.

28. Liao, Y.-C., Li, H.-P., Yao, M.-J., Zhang, J.-B., Liu, J.-L. Plantibodies: A novel strategy to create pathogen-resistant plants. Biotechnology and Genetic Engineering Reviews, 2006, 23:253-271.


其他作者中文文章

1. 宫安东,孔宪巍,翟新可,路亚南,文淑婷,张静柏. 枯草芽胞杆菌WY8-7的溶磷、抑菌及促生长作用. 南京农业大学学报,2019424):697-705

2. 何伟杰,刘易科,朱展望,张静柏,高春保,廖玉才. 镰刀菌毒素脱氧雪腐镰刀菌烯醇脱毒菌及脱毒酶研究进展. 植物病理学报,2019495):577-589

3. 胡祖权,李和平,张静柏,刘锦龙,廖玉才. 伏马菌素B1特异单链抗体的同源建模及分子对接模拟研究. 免疫学杂志,2015317):618-622

4. 李和平,张静柏,廖玉才. 绿色荧光蛋白基因在小麦禾谷镰刀菌中的表达与鉴定. 麦类作物学报,2010305): 824-828

5. 刘春雷,廖玉才,张静柏,黄涛,李和平. 赤霉病菌特异抗体-防御素融合蛋白的表达和功能鉴定. bet体育在线官网学报,2007264):435-438

6. 武爱波,李和平,张静柏,赵纯森,姚明镜,SCHOLTEN Olga,廖玉才. 中国与欧洲禾谷镰刀菌DON毒素HPLC定量比较分析. 应用与环境生物学报,2007131):131-134

7. 武爱波,李和平,张静柏,姚明镜,许玉彬,廖玉才. 小麦和玉米籽粒赤霉菌产毒类型的PCR检测. 麦类作物学报,2005255):1-4


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